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KMID : 0848120130380020061
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International Journal of Oral Biology
2013 Volume.38 No. 2 p.61 ~ p.65
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Incidence of Erythromycin Resistance Genes, erm(B) and mef(A), in Streptococci Isolated from Dental Plaques of Koreans
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Lee Si-Young
Kim Yeon-Hee
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Abstract
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Erythromycin is a macrolide antibiotic and inhibits bacterialprotein synthesis by stimulating the dissociation of thepeptidyl-tRNA molecule from the ribosomes during elongation.The use of macrolides has increased dramaticallyover the last few years and has led to an increase in bacterialresistance to these antibiotics. Bacterial resistance toerythromycin is generally conferred by the ribosome methylationand/or transport (efflux) protein genes. Among theidentified erythromycin-resistant genes, erm(B) (erythromycinmethylation) and mef(A) (macrolide efflux) are generallydetectable in erythromycin-resistant streptococcal species.The distribution of these genes in oral streptococcal isolateshas been reported in studies from other countries buthas not been previously examined in a Korean study. We hereexamined by PCR the presence of erm(B) and mef(A) inoral streptococci isolated from Korean dental plaques. Amongthe 57 erythromycin-resistant strains tested, 64.9% harborederm(B) whereas 40.4% were positive for mef(A). Elevenisolates had both the erm(B) and mef(A) genes. Twenty sixisolates had only erm(B) and 12 isolates had only mef(A).Eight of the 57 strains examined were negative for both genes.
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KEYWORD
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Erythromycin, Resistance, Streptococci
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